PRNP

Across TCGA patient cohorts, PRNP protein abundance is significantly associated with the RNA expression of many other genes, with 13,170 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PRNP-associated genes across cancer lineages are GPR85, CNRIP1, and FEZ1. Each is linked with PRNP in more than 4 cancer types. Because this analysis shows association rather than direction, both PRNP-to-partner and partner-to-PRNP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRNP versus GPR85 in GBM, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRNP→partner) and Y-score (partner→PRNP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GPR85 →	+0.688	+0.587	<.001	<.001	3	5
UCEC	CNRIP1 →	+0.725	+0.625	.001	<.001	3	5
GBM	FEZ1 →	+0.587	+0.503	<.001	<.001	3	5
GBM	VSNL1 →	+1.803	+0.484	<.001	<.001	3	4
LUAD	RAB7B →	+0.970	+0.333	.001	<.001	3	4
UCEC	RAB9B →	+0.712	+0.717	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,170 associations by consensus.

PRNP vs GPR85 — GBM

Explore this scatter interactively →