PRNP

Across TCGA patient cohorts, PRNP mutation is significantly associated with the RNA expression of many other genes, with 2,001 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRNP-associated genes across cancer lineages are MIR7-3, ZNF736P7Y, and SPPL2C. Each is linked with PRNP in more than 2 cancer types. Because this analysis shows association rather than direction, both PRNP-to-partner and partner-to-PRNP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7-3 grouped by PRNP-low versus PRNP-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRNP→partner) and Y-score (partner→PRNP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR7-3 →	+0.689	+6.444	<.001	.001	3	3
STAD	ZNF736P7Y →	+0.093	+5.621	<.001	<.001	3	3
CESC	SPPL2C →	+0.025	+4.601	<.001	.004	3	2
CESC	RNU6-429P →	+0.257	+6.164	<.001	<.001	3	2
SKCM	RNU7-81P →	+0.530	+6.328	<.001	.001	3	2
CESC	LINC02758 →	+0.106	+5.269	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,001 associations by consensus.

MIR7-3 by PRNP expression — LUAD

Explore this box plot interactively →