PRNP

Across TCGA cell cohorts, PRNP RNA expression is significantly associated with the go_rna of many other GO terms, with 5,565 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PRNP-associated GO terms across cancer lineages are Negative regulation of dendritic spine maintenance, Proteoglycan biosynthetic process, and Wound healing. Each is linked with PRNP in more than 13 cancer types. Because this analysis shows association rather than direction, both PRNP-to-partner and partner-to-PRNP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of dendritic spine maintenance grouped by PRNP-low versus PRNP-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRNP→partner) and Y-score (partner→PRNP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Negative regulation of dendritic spine maintenance →	+0.277	+1.618	.001	.001	3	14
BONE	Proteoglycan biosynthetic process →	+0.099	+1.410	<.001	<.001	3	13
BONE	Wound healing →	+0.106	+1.014	<.001	<.001	3	13
BREAST	Regulation of protein maturation →	+0.186	+2.786	<.001	<.001	3	13
BONE	Positive regulation of retrograde protein transport, ER to cytosol →	+0.195	+1.497	<.001	<.001	3	13
SOFT_TISSUE	Maintenance of protein location →	+0.167	+1.747	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,565 associations by consensus.

Negative regulation of dendritic spine maintenance by PRNP expression — BLOOD_Myeloma

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