PRND

Across TCGA patient cohorts, PRND mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRND-associated genes across cancer lineages are Cyclin-B1, EGFR_pY1068, and FASN. Each is linked with PRND in more than 2 cancer types. Because this analysis shows association rather than direction, both PRND-to-partner and partner-to-PRND results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PRND-low versus PRND-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRND→partner) and Y-score (partner→PRND) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.945	+2.662	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.286	-2.169	.002	.003	3	2
UCEC	FASN →	+0.393	+2.169	.007	.003	3	2
UCEC	TFRC →	+0.447	+2.321	.024	.033	3	2
COAD	Caspase-7-cleavedD198 →	+1.015	+2.467	.003	.011	3	2
UCEC	4E-BP1 →	+0.325	+3.730	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Cyclin-B1 by PRND expression — UCEC

Explore this box plot interactively →