PRMT9

Across TCGA patient cohorts, PRMT9 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRMT9-associated genes across cancer lineages are ACC1, JNK_pT183_Y185, and cIAP. Each is linked with PRMT9 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRMT9-to-partner and partner-to-PRMT9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by PRMT9-low versus PRMT9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT9→partner) and Y-score (partner→PRMT9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.326	+2.598	.009	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.219	-2.906	<.001	.001	3	2
UCEC	cIAP →	+0.100	+1.594	.035	.042	3	2
UCEC	53BP1 →	+0.375	+2.222	.001	.009	3	2
UCEC	14-3-3_beta →	-0.100	-1.780	.004	.024	3	1
UCEC	EGFR_pY1068 →	-0.288	-2.070	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ACC1 by PRMT9 expression — UCEC

Explore this box plot interactively →