PRMT7

Across TCGA patient cohorts, PRMT7 mutation is significantly associated with the RNA expression of many other genes, with 1,378 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRMT7-associated genes across cancer lineages are AP1B1, TXN2, and TANGO6. Each is linked with PRMT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRMT7-to-partner and partner-to-PRMT7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AP1B1 grouped by PRMT7-low versus PRMT7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT7→partner) and Y-score (partner→PRMT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AP1B1 →	+0.347	+2.353	.006	.003	3	2
UCEC	TXN2 →	+0.314	+2.939	.001	<.001	3	2
UCEC	TANGO6 →	+0.493	+2.330	<.001	.003	3	2
UCEC	TTC23 →	+0.287	+2.711	.008	.003	3	2
UCEC	GNPDA1 →	+0.425	+2.186	<.001	.001	3	2
UCEC	TNFSF9 →	+0.798	+2.643	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,378 associations by consensus.

AP1B1 by PRMT7 expression — UCEC

Explore this box plot interactively →