PRMT7

Across TCGA cell cohorts, PRMT7 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRMT7-associated genes across cancer lineages are USP17L11, KRTAP21-2, and ADAD1. Each is linked with PRMT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRMT7-to-partner and partner-to-PRMT7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L11 grouped by PRMT7-low versus PRMT7-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT7→partner) and Y-score (partner→PRMT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	USP17L11 →	+0.016	+5.415	<.001	.004	3	2
BLOOD_Leukemia	KRTAP21-2 →	+0.085	+5.539	<.001	.003	3	2
BLOOD_Lymphoma	ADAD1 →	+0.217	+4.169	<.001	.002	3	1
BLOOD_Lymphoma	LIPF →	+0.044	+3.807	.003	.007	3	1
BLOOD_Lymphoma	MUC22 →	+0.064	+3.714	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

USP17L11 by PRMT7 expression — SKIN

Explore this box plot interactively →