Across TCGA patient cohorts, PRMT6 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRMT6-associated genes across cancer lineages are ASNS, PDCD4, and ATM. Each is linked with PRMT6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRMT6-to-partner and partner-to-PRMT6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT6→partner) and Y-score (partner→PRMT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.730	+2.178	<.001	.035	3	3
UCEC	PDCD4 →	-0.568	-1.797	<.001	.025	3	2
UCEC	ATM →	-0.644	-2.807	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.789	+2.222	<.001	.009	3	2
UCEC	4E-BP1 →	+0.392	+3.807	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.216	-1.584	.017	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

PRMT6 survival (RNA) · tumor vs normal (RNA) · all PRMT6 data types