Across TCGA cell cohorts, PRMT6 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRMT6-associated genes across cancer lineages are H1-8, CST11, and CSN2. Each is linked with PRMT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRMT6-to-partner and partner-to-PRMT6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT6→partner) and Y-score (partner→PRMT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	H1-8 →	+0.033	+4.887	<.001	.009	3	2
CNS	CST11 →	+0.065	+4.981	.006	.008	3	2
BLOOD_Leukemia	CSN2 →	+0.017	+4.969	<.001	.003	3	1
BLOOD_Leukemia	KIR3DL1 →	+0.044	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10Q1 →	+0.027	+4.969	<.001	.003	3	1
BLOOD_Leukemia	SI →	+0.069	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

PRMT6 survival (RNA) · tumor vs normal (RNA) · all PRMT6 data types