PRMT5

Across TCGA patient cohorts, PRMT5 protein abundance is significantly associated with the RNA expression of many other genes, with 15,885 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRMT5-associated genes across cancer lineages are MRPL52, NOP9, and GSTZ1. Each is linked with PRMT5 in more than 8 cancer types. Because this analysis shows association rather than direction, both PRMT5-to-partner and partner-to-PRMT5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRMT5 versus MRPL52 in BRCA, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT5→partner) and Y-score (partner→PRMT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MRPL52 →	+0.669	+0.281	<.001	<.001	3	9
COAD	NOP9 →	+0.639	+0.334	<.001	<.001	3	8
COAD	GSTZ1 →	+0.666	+0.281	<.001	<.001	3	7
HNSC	CCNB1IP1 →	+0.816	+0.233	.001	<.001	3	7
LSCC	APEX1 →	+0.599	+0.289	<.001	<.001	3	7
LSCC	OXA1L →	+0.512	+0.322	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,885 associations by consensus.

PRMT5 vs MRPL52 — BRCA

Explore this scatter interactively →