PRMT5

Across TCGA patient cohorts, PRMT5 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRMT5-associated genes across cancer lineages are p62 Lck ligand, PCNA, and 4E-BP1_pT37_T46. Each is linked with PRMT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRMT5-to-partner and partner-to-PRMT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PRMT5-low versus PRMT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT5→partner) and Y-score (partner→PRMT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.350	+2.807	.013	.003	3	2
UCEC	PCNA →	+0.207	+2.115	.028	.019	3	2
UCEC	4E-BP1_pT37_T46 →	-0.475	-3.308	.003	.009	3	2
SKCM	4E-BP1_pT70 →	+0.242	+2.186	.009	.034	3	1
UCEC	EGFR_pY1068 →	-0.281	-2.115	.010	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.168	-2.102	.022	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

p62 Lck ligand by PRMT5 expression — UCEC

Explore this box plot interactively →