PRMT5

Across TCGA cell cohorts, PRMT5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,956 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRMT5-associated GO terms across cancer lineages are rRNA 5'-end processing, Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with PRMT5 in more than 17 cancer types. Because this analysis shows association rather than direction, both PRMT5-to-partner and partner-to-PRMT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA 5'-end processing grouped by PRMT5-low versus PRMT5-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT5→partner) and Y-score (partner→PRMT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	rRNA 5'-end processing →	+0.124	+0.785	.006	.005	3	18
BONE	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.138	+0.987	<.001	<.001	3	18
URINARY_TRACT	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.140	+0.926	<.001	.001	3	18
BLOOD_Myeloma	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.124	+0.785	.006	.005	3	18
KIDNEY	Pericentric heterochromatin formation →	+0.172	+1.025	.001	.001	3	17
URINARY_TRACT	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.121	+1.229	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,956 associations by consensus.

rRNA 5'-end processing by PRMT5 expression — BLOOD_Myeloma

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