PRMT5-AS1

Across TCGA pan-cancer cohorts, PRMT5-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PRMT5-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PRMT5-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRMT5-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

KIRC, ACC, and UVM are the cancer types where PRMT5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.522	0.709	<.001	109	view →
ACC	DFS	Median	All	0.209	0.676	<.001	107	view →
UVM	DFS	Quartile	III,IV	0.186	0.844	.001	59	view →
LIHC	DFS	Tertile	All	0.324	0.508	<.001	55	view →
BRCA	OS	Quartile	II,III,IV	0.976	0.914	.001	40	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
LUAD	DFS	Median	IV	0.260	0.741	.007	21	view →
SKCM	DFS	Median	II,III,IV	0.186	0.419	.001	21	view →
PRAD	DFS	Median	All	0.814	0.940	<.001	16	view →
LGG	DFS	Quartile	All	0.772	0.882	.002	12	view →
KICH	OS	Quartile	II,III,IV	0.412	0.879	.039	11	view →
HNSC	OS	Quartile	III,IV	0.402	0.683	.013	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PRMT5-AS1–KIRC (DFS)

Open the KIRC breakdown →