PRMT2

Across TCGA patient cohorts, PRMT2 mutation is significantly associated with the RNA expression of many other genes, with 4,640 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRMT2-associated genes across cancer lineages are TAF13, C1orf174, and DCLRE1A. Each is linked with PRMT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRMT2-to-partner and partner-to-PRMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAF13 grouped by PRMT2-low versus PRMT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT2→partner) and Y-score (partner→PRMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAF13 →	+0.719	+2.754	<.001	<.001	3	3
COAD	C1orf174 →	+0.499	+3.509	<.001	.002	3	3
COAD	DCLRE1A →	+0.577	+3.489	<.001	.002	3	3
UCEC	C4orf46 →	+0.716	+2.080	<.001	<.001	3	3
COAD	PPP3R1 →	+0.438	+2.611	.001	.006	3	3
UCEC	ORC6 →	+0.806	+3.233	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,640 associations by consensus.

TAF13 by PRMT2 expression — UCEC

Explore this box plot interactively →