PRMT2

Across TCGA patient cohorts, PRMT2 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRMT2-associated genes across cancer lineages are Notch1, eEF2, and MEK1. Each is linked with PRMT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRMT2-to-partner and partner-to-PRMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PRMT2-low versus PRMT2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT2→partner) and Y-score (partner→PRMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Notch1 →	+0.180	+2.178	.038	.035	3	3
UCEC	eEF2 →	+0.307	+3.169	.015	.018	3	2
UCEC	MEK1 →	+0.456	+2.662	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.117	-1.680	.026	.042	3	2
COAD	PCNA →	+0.359	+3.330	.002	.005	3	2
UCEC	PDCD4 →	-0.363	-1.362	.029	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Notch1 by PRMT2 expression — COAD

Explore this box plot interactively →