PRMT2

Across TCGA cell cohorts, PRMT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,306 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PRMT2-associated GO terms across cancer lineages are Regulation of stress-activated protein kinase signaling cascade, Regulation of focal adhesion assembly, and Caveolin-mediated endocytosis. Each is linked with PRMT2 in more than 12 cancer types. Because this analysis shows association rather than direction, both PRMT2-to-partner and partner-to-PRMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of stress-activated protein kinase signaling cascade grouped by PRMT2-low versus PRMT2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT2→partner) and Y-score (partner→PRMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of stress-activated protein kinase signaling cascade →	+0.123	+0.818	.003	.002	3	13
LARGE_INTESTINE	Regulation of focal adhesion assembly →	+0.109	+0.848	<.001	<.001	3	12
LARGE_INTESTINE	Caveolin-mediated endocytosis →	+0.200	+0.884	<.001	<.001	3	12
LARGE_INTESTINE	Regulation of cell-substrate junction assembly →	+0.109	+0.848	<.001	<.001	3	12
BREAST	Cell division →	+0.111	+1.232	<.001	<.001	3	11
BREAST	Cytoskeleton-dependent cytokinesis →	+0.084	+1.083	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,306 associations by consensus.

Regulation of stress-activated protein kinase signaling cascade by PRMT2 expression — LIVER

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