PRMT2

Across TCGA cell cohorts, PRMT2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRMT2-associated genes across cancer lineages are GML, IL2, and SLC35G3. Each is linked with PRMT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRMT2-to-partner and partner-to-PRMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by PRMT2-low versus PRMT2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT2→partner) and Y-score (partner→PRMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.091	+4.152	<.001	.009	3	1
BLOOD_Leukemia	IL2 →	+1.010	+4.276	<.001	.007	3	1
BLOOD_Leukemia	SLC35G3 →	+0.075	+4.874	<.001	.002	3	1
BLOOD_Leukemia	GPR101 →	+0.167	+4.551	<.001	.004	3	1
BLOOD_Leukemia	SYCN →	+0.035	+4.539	<.001	.007	3	1
BLOOD_Leukemia	NKX2-6 →	+0.507	+5.786	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

GML by PRMT2 expression — BLOOD_Leukemia

Explore this box plot interactively →