PRMT1

Across TCGA patient cohorts, PRMT1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRMT1-associated genes across cancer lineages are Annexin-1, Cyclin-B1, and 14-3-3_beta. Each is linked with PRMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRMT1-to-partner and partner-to-PRMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by PRMT1-low versus PRMT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT1→partner) and Y-score (partner→PRMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.638	+2.019	<.001	.017	3	2
UCEC	Cyclin-B1 →	+0.440	+1.502	.033	.030	3	2
UCEC	14-3-3_beta →	-0.097	-2.432	.008	.018	3	1
UCEC	eEF2 →	+0.276	+1.502	.035	.030	3	1
UCEC	EGFR_pY1068 →	-0.246	-1.847	.007	.008	3	1
UCEC	ACC_pS79 →	+0.298	+1.502	.019	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Annexin-1 by PRMT1 expression — UCEC

Explore this box plot interactively →