PRM3

Across TCGA patient cohorts, PRM3 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PRM3-associated genes across cancer lineages are RNU6-440P, RNU6-1290P, and RNU4-73P. Each is linked with PRM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRM3-to-partner and partner-to-PRM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-440P grouped by PRM3-low versus PRM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRM3→partner) and Y-score (partner→PRM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-440P →	+0.227	+4.464	<.001	.005	3	2
COAD	RNU6-1290P →	+1.191	+5.251	<.001	.003	3	1
COAD	RNU4-73P →	+0.807	+4.181	<.001	.009	3	1
COAD	RNU6-1249P →	+0.456	+5.917	<.001	.001	3	1
COAD	RNU5E-8P →	+0.314	+6.142	.004	<.001	3	1
COAD	RNU6-194P →	+0.890	+4.577	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

RNU6-440P by PRM3 expression — UCEC

Explore this box plot interactively →