PRM2

Across TCGA patient cohorts, PRM2 mutation is significantly associated with the RNA expression of many other genes, with 552 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRM2-associated genes across cancer lineages are TRGJP2, MIR4804, and RNU6-1169P. Each is linked with PRM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRM2-to-partner and partner-to-PRM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRGJP2 grouped by PRM2-low versus PRM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRM2→partner) and Y-score (partner→PRM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRGJP2 →	+0.552	+2.014	<.001	.009	3	2
UCEC	MIR4804 →	+0.353	+2.870	<.001	.001	3	2
SKCM	RNU6-1169P →	+0.296	+4.362	<.001	.001	3	2
HNSC	LINC00251 →	+0.047	+5.008	<.001	.004	3	1
UCEC	YPEL5P2 →	+0.318	+2.416	.002	.001	3	1
UCEC	MESTIT1 →	-0.213	-2.906	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 552 associations by consensus.

TRGJP2 by PRM2 expression — UCEC

Explore this box plot interactively →