PRM2

Across TCGA patient cohorts, PRM2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRM2-associated genes across cancer lineages are FOXO3a_pS318_S321, MEK1, and Notch1. Each is linked with PRM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRM2-to-partner and partner-to-PRM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by PRM2-low versus PRM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRM2→partner) and Y-score (partner→PRM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.150	-2.321	.017	.035	3	1
UCEC	MEK1 →	+0.419	+3.169	.022	.019	3	1
UCEC	Notch1 →	+0.150	+2.321	.034	.035	3	1
UCEC	PDCD4 →	-0.691	-2.321	.003	.035	3	1
UCEC	Shc_pY317 →	-0.162	-3.000	.034	.036	3	1
UCEC	c-Jun_pS73 →	-0.172	-2.321	.031	.035	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FOXO3a_pS318_S321 by PRM2 expression — UCEC

Explore this box plot interactively →