PRM1

Across TCGA patient cohorts, PRM1 mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRM1-associated genes across cancer lineages are MRPL51P2, FTH1P9, and KIR3DL1. Each is linked with PRM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRM1-to-partner and partner-to-PRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL51P2 grouped by PRM1-low versus PRM1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRM1→partner) and Y-score (partner→PRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MRPL51P2 →	+0.114	+7.640	<.001	.009	3	2
BLCA	FTH1P9 →	+0.104	+7.640	<.001	.009	3	2
UCEC	KIR3DL1 →	+0.456	+3.495	<.001	.008	3	1
UCEC	RAX2 →	+0.825	+3.484	<.001	.008	3	1
UCEC	IGHV4-4 →	+2.108	+3.953	<.001	.002	3	1
SKCM	MIR7845 →	+0.696	+5.034	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

MRPL51P2 by PRM1 expression — BLCA

Explore this box plot interactively →