PRLR

Across TCGA patient cohorts, PRLR RNA expression is significantly associated with the protein abundance of many other proteins, with 14,918 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PRLR-associated proteins across cancer lineages are SEPHS2, RBM47, and DDAH2. Each is linked with PRLR in more than 4 cancer types. Because this analysis shows association rather than direction, both PRLR-to-partner and partner-to-PRLR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRLR versus SEPHS2 in BRCA, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PRLR→partner) and Y-score (partner→PRLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEPHS2 →	+0.494	+1.377	<.001	<.001	3	5
GBM	RBM47 →	+0.435	+0.298	<.001	<.001	3	4
COAD	DDAH2 →	+0.393	+0.985	.001	<.001	3	4
BRCA	FARP1 →	+0.447	+1.413	<.001	<.001	3	4
CCRCC	CLINT1 →	+0.200	+0.958	<.001	<.001	3	4
GBM	EGFR →	-1.281	-0.388	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,918 associations by consensus.

PRLR vs SEPHS2 — BRCA

Explore this scatter interactively →