PRLR

Across TCGA patient cohorts, PRLR protein abundance is significantly associated with the RNA expression of many other genes, with 4,837 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PRLR-associated genes across cancer lineages are COL11A2P1, GTPBP1, and SLC7A6. Each is linked with PRLR in more than 1 cancer types. Because this analysis shows association rather than direction, both PRLR-to-partner and partner-to-PRLR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRLR versus COL11A2P1 in HNSC, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRLR→partner) and Y-score (partner→PRLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	COL11A2P1 →	+0.133	+0.546	.001	.008	3	2
BRCA	GTPBP1 →	+0.535	+0.577	.002	<.001	3	1
BRCA	SLC7A6 →	+0.451	+0.449	.002	.004	3	1
BRCA	ZDHHC2 →	+1.046	+0.525	<.001	<.001	3	1
BRCA	MEGF9 →	+0.883	+0.613	.007	.003	3	1
BRCA	EPM2A →	+0.286	+0.477	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,837 associations by consensus.

PRLR vs COL11A2P1 — HNSC

Explore this scatter interactively →