PRLR

Across TCGA patient cohorts, PRLR mutation is significantly associated with the RNA expression of many other genes, with 4,348 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRLR-associated genes across cancer lineages are KIAA1841, PXMP2, and MRPS15. Each is linked with PRLR in more than 2 cancer types. Because this analysis shows association rather than direction, both PRLR-to-partner and partner-to-PRLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIAA1841 grouped by PRLR-low versus PRLR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRLR→partner) and Y-score (partner→PRLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIAA1841 →	+0.489	+2.188	<.001	.008	3	3
UCEC	PXMP2 →	+0.699	+1.923	<.001	.009	3	3
UCEC	MRPS15 →	+0.382	+3.501	.003	.002	3	3
UCEC	RNFT2 →	+0.577	+2.946	<.001	<.001	3	3
LUAD	BNIP3P41 →	+0.027	+4.000	<.001	.009	3	3
SARC	OR10J9P →	+0.073	+6.380	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,348 associations by consensus.

KIAA1841 by PRLR expression — UCEC

Explore this box plot interactively →