PRLR

Across TCGA patient cohorts, PRLR mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRLR-associated genes across cancer lineages are eEF2, p38-MAPK_pT180_Y182, and PCNA. Each is linked with PRLR in more than 1 cancer types. Because this analysis shows association rather than direction, both PRLR-to-partner and partner-to-PRLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PRLR-low versus PRLR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRLR→partner) and Y-score (partner→PRLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.465	+3.459	.001	.005	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.538	-1.893	.002	.016	3	2
UCEC	PCNA →	+0.323	+3.087	<.001	<.001	3	2
SKCM	ACC_pS79 →	+0.176	+1.247	.042	.038	3	2
SKCM	Lck →	-0.223	-1.700	.025	.038	3	2
SKCM	Src →	-0.173	-1.184	.011	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

eEF2 by PRLR expression — UCEC

Explore this box plot interactively →