PRLR

Across TCGA cell cohorts, PRLR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,029 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PRLR-associated GO terms across cancer lineages are Prolactin signaling pathway, Activation of transmembrane receptor protein tyrosine kinase activity, and Regulation of ferroptosis. Each is linked with PRLR in more than 13 cancer types. Because this analysis shows association rather than direction, both PRLR-to-partner and partner-to-PRLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Prolactin signaling pathway grouped by PRLR-low versus PRLR-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRLR→partner) and Y-score (partner→PRLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Prolactin signaling pathway →	-0.360	-1.609	<.001	<.001	3	14
SKIN	Activation of transmembrane receptor protein tyrosine kinase activity →	-0.381	-0.739	<.001	<.001	3	10
BONE	Regulation of ferroptosis →	+0.123	+0.365	.008	.005	2	8
BONE	Vesicle-mediated transport to the plasma membrane →	+0.072	+0.385	.001	.004	3	7
BONE	Regulation of protein exit from endoplasmic reticulum →	+0.146	+0.296	<.001	.007	3	6
OVARY	Regulation of Golgi organization →	+0.087	+0.348	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,029 associations by consensus.

Prolactin signaling pathway by PRLR expression — LIVER

Explore this box plot interactively →