PRLR

Across TCGA cell cohorts, PRLR mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PRLR-associated genes across cancer lineages are MRGPRX1, PRAMEF10, and MAGEB5. Each is linked with PRLR in more than 1 cancer types. Because this analysis shows association rather than direction, both PRLR-to-partner and partner-to-PRLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGPRX1 grouped by PRLR-low versus PRLR-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRLR→partner) and Y-score (partner→PRLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MRGPRX1 →	+0.129	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1
LUNG_SCLC	MAGEB5 →	+0.012	+4.058	<.001	.007	3	1
LUNG_SCLC	SULT1C3 →	+0.161	+3.523	.003	.008	3	1
LUNG_SCLC	PRAMEF17 →	+0.008	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF25 →	+0.134	+3.523	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MRGPRX1 by PRLR expression — LUNG_SCLC

Explore this box plot interactively →