PRL

Across TCGA patient cohorts, PRL mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRL-associated genes across cancer lineages are Cyclin-E1, ERK2, and JNK_pT183_Y185. Each is linked with PRL in more than 2 cancer types. Because this analysis shows association rather than direction, both PRL-to-partner and partner-to-PRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E1 grouped by PRL-low versus PRL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRL→partner) and Y-score (partner→PRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E1 →	+0.351	+1.584	.039	.036	3	3
UCEC	ERK2 →	+0.228	+2.584	.002	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.150	-1.571	.023	.036	3	1
UCEC	JNK2 →	+0.286	+2.348	<.001	.018	3	1
UCEC	MEK1 →	+0.441	+2.000	.002	.010	3	1
UCEC	MSH2 →	-0.325	-2.558	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Cyclin-E1 by PRL expression — UCEC

Explore this box plot interactively →