PRL

Across TCGA cell cohorts, PRL RNA expression is significantly associated with the go_rna of many other GO terms, with 749 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PRL-associated GO terms across cancer lineages are Mitochondrial respiratory chain complex assembly, Maintenance of blood-brain barrier, and Positive regulation of miRNA metabolic process. Each is linked with PRL in more than 3 cancer types. Because this analysis shows association rather than direction, both PRL-to-partner and partner-to-PRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial respiratory chain complex assembly grouped by PRL-low versus PRL-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRL→partner) and Y-score (partner→PRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Mitochondrial respiratory chain complex assembly →	+0.051	+1.023	.005	.003	3	4
OESOPHAGUS	Maintenance of blood-brain barrier →	-0.156	-0.019	<.001	.009	3	4
BONE	Positive regulation of miRNA metabolic process →	-0.104	-0.209	.004	.008	3	4
CNS	Specification of symmetry →	-0.024	-0.140	.006	.005	3	3
CNS	Determination of bilateral symmetry →	-0.024	-0.140	.006	.005	3	3
BLOOD_Leukemia	Negative regulation of alpha-beta T cell differentiation →	-0.061	-0.591	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 749 associations by consensus.

Mitochondrial respiratory chain complex assembly by PRL expression — LUNG_SCLC

Explore this box plot interactively →