PRL

Across TCGA cell cohorts, PRL mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible PRL-associated genes across cancer lineages are TAFA1, OR1L1, and OR4D11. Each is linked with PRL in more than 1 cancer types. Because this analysis shows association rather than direction, both PRL-to-partner and partner-to-PRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAFA1 grouped by PRL-low versus PRL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRL→partner) and Y-score (partner→PRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
OVARY	OR1L1 →	+0.036	+5.196	<.001	.005	3	1
OVARY	OR4D11 →	+0.023	+5.807	<.001	.001	3	1
OVARY	IQCF2 →	+0.055	+5.196	<.001	.005	3	1
OVARY	ODF4 →	+0.042	+5.196	<.001	.005	3	1
LARGE_INTESTINE	EFHC2 →	+0.506	+3.333	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TAFA1 by PRL expression — LARGE_INTESTINE

Explore this box plot interactively →