PRKXP1

Across TCGA pan-cancer cohorts, PRKXP1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PRKXP1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PRKXP1 RNA is repressed in tumor relative to normal tissue. In most cancer types PRKXP1 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, STAD, and KIRP are the cancer types where PRKXP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKXP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.920	<.001	10	view →
STAD	All	II,III,IV	+0.519	.010	5	view →
KIRP	Female	II,III,IV	−0.580	.006	4	view →
BRCA	Female	All	−0.248	.021	4	view →
LUAD	Female	II,III,IV	−0.567	.025	3	view →
CHOL	All	All	+0.781	.014	2	view →
ESCA	Female	All	+0.893	.005	1	view →
KICH	All	All	−0.298	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PRKXP1–THCA

Open the THCA breakdown →