PRKX

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PRKX mutation is significantly associated with the RNA expression of many other genes, with 2,524 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKX-associated genes across cancer lineages are RNU6-222P, RN7SKP181, and RNU6-718P. Each is linked with PRKX in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKX-to-partner and partner-to-PRKX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKX→partner) and Y-score (partner→PRKX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECRNU6-222P →+0.283+1.861.001.00632
UCECRN7SKP181 →+0.081+2.133.002.00732
UCECRNU6-718P →+0.100+3.002.005.00632
UCECRNU6-1069P →+0.847+1.700<.001.00432
SKCMRNU1-17P →+0.188+4.147<.001.00832
UCECCCL5 →+1.149+2.021<.001.00131
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,524 associations by consensus.

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