Across TCGA patient cohorts, PRKX mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKX-associated genes across cancer lineages are FoxM1, EGFR_pY1068, and A-Raf_pS299. Each is linked with PRKX in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKX-to-partner and partner-to-PRKX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKX→partner) and Y-score (partner→PRKX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.242	+2.594	.010	.006	3	2
UCEC	EGFR_pY1068 →	-0.239	-1.847	.009	.008	3	1
UCEC	A-Raf_pS299 →	-0.152	-2.807	<.001	.003	3	1
UCEC	ERK2 →	+0.233	+2.807	<.001	.003	3	1
UCEC	Gab2 →	+0.304	+1.847	.020	.008	3	1
UCEC	Ku80 →	+0.184	+1.750	.034	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

PRKX survival (RNA) · tumor vs normal (RNA) · all PRKX data types