PRKRA

Across TCGA pan-cancer cohorts, PRKRA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PRKRA data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PRKRA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRKRA expression acts as an unfavorable survival marker.

HNSC, LUAD, and CCRCC are the cancer types where PRKRA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.900	1.000	.003	10	view →
LUAD	OS	Median	II,III,IV	0.782	1.000	.003	8	view →
CCRCC	OS	Median	II,III,IV	0.339	1.000	.003	7	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	4	view →
LSCC	DFS	Quartile	III,IV	0.771	1.000	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PRKRA–HNSC (DFS)

Open the HNSC breakdown →