PRKRA

Across TCGA patient cohorts, PRKRA mutation is significantly associated with the RNA expression of many other genes, with 3,209 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKRA-associated genes across cancer lineages are LINC02221, SNX3P1Y, and TRGJP2. Each is linked with PRKRA in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKRA-to-partner and partner-to-PRKRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02221 grouped by PRKRA-low versus PRKRA-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKRA→partner) and Y-score (partner→PRKRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LINC02221 →	+0.103	+5.368	<.001	.005	3	2
UCEC	SNX3P1Y →	+0.098	+4.478	<.001	.003	3	2
UCEC	TRGJP2 →	+0.620	+2.566	<.001	<.001	3	2
BRCA	LINC02342 →	+0.078	+7.731	.002	.009	3	1
HNSC	NUP210P2 →	+0.183	+6.111	<.001	.002	3	1
HNSC	SFTPA3P →	+0.193	+5.912	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,209 associations by consensus.

LINC02221 by PRKRA expression — HNSC

Explore this box plot interactively →