PRKRA

Across TCGA cell cohorts, PRKRA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,082 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRKRA-associated GO terms across cancer lineages are Regulation of DNA damage checkpoint, Regulation of chromosome segregation, and Regulation of cell cycle checkpoint. Each is linked with PRKRA in more than 15 cancer types. Because this analysis shows association rather than direction, both PRKRA-to-partner and partner-to-PRKRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA damage checkpoint grouped by PRKRA-low versus PRKRA-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKRA→partner) and Y-score (partner→PRKRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of DNA damage checkpoint →	+0.084	+0.945	<.001	<.001	3	16
BREAST	Regulation of chromosome segregation →	+0.116	+0.714	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Regulation of cell cycle checkpoint →	+0.112	+0.782	.001	.008	2	15
SOFT_TISSUE	Positive regulation of cell cycle →	+0.084	+0.570	<.001	<.001	3	14
KIDNEY	Positive regulation of cell cycle process →	+0.073	+0.672	.001	.001	3	13
LUNG_NSCLC_LUSC	Regulation of endoplasmic reticulum tubular network organization →	+0.127	+0.771	.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,082 associations by consensus.

Regulation of DNA damage checkpoint by PRKRA expression — BREAST

Explore this box plot interactively →