Across TCGA pan-cancer cohorts, PRKN mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PRKN data layer compared with 25 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PRKN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRKN expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where PRKN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	III,IV	0.483	1.000	.013	20	view →
LUAD	DFS	Quartile	III,IV	0.411	0.948	.002	17	view →
CCRCC	OS	Median	III,IV	1.000	0.781	.007	16	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: PRKN tumor-vs-normal RNA expression · all PRKN data types