PRKG2

Across TCGA cell cohorts, PRKG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,902 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKG2-associated GO terms across cancer lineages are Tetrahydrobiopterin metabolic process, Regulation of syncytium formation by plasma membrane fusion, and Regulation of myoblast fusion. Each is linked with PRKG2 in more than 9 cancer types. Because this analysis shows association rather than direction, both PRKG2-to-partner and partner-to-PRKG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tetrahydrobiopterin metabolic process grouped by PRKG2-low versus PRKG2-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKG2→partner) and Y-score (partner→PRKG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Tetrahydrobiopterin metabolic process →	-0.117	-1.054	<.001	<.001	3	10
STOMACH	Regulation of syncytium formation by plasma membrane fusion →	+0.108	+0.846	.001	<.001	2	9
STOMACH	Regulation of myoblast fusion →	+0.107	+0.806	.002	<.001	3	7
LARGE_INTESTINE	Regulation of protein kinase activity →	+0.042	+0.902	<.001	<.001	3	7
STOMACH	miRNA processing →	+0.072	+0.545	.001	.005	3	7
UPPER_AERODIGESTIVE_TRACT	Positive regulation of T cell differentiation →	+0.048	+0.459	.002	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,902 associations by consensus.

Tetrahydrobiopterin metabolic process by PRKG2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →