PRKG2

Across TCGA cell cohorts, PRKG2 mutation is significantly associated with the drug of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKG2-associated genes across cancer lineages are 123829, LY2109761, and KRAS (G12C) Inhibitor-12. Each is linked with PRKG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKG2-to-partner and partner-to-PRKG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 123829 grouped by PRKG2-low versus PRKG2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKG2→partner) and Y-score (partner→PRKG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	123829 →	+0.656	+2.649	.023	.046	3	1
LARGE_INTESTINE	LY2109761 →	+0.427	+2.646	.010	.047	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.739	+2.646	.002	.047	3	1
LARGE_INTESTINE	QL-XI-92 →	+0.366	+2.652	.034	.045	3	1
LARGE_INTESTINE	Dinaciclib →	+0.574	+2.646	.025	.047	1	1
LARGE_INTESTINE	Teniposide →	+0.818	+2.649	.001	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

123829 by PRKG2 expression — LARGE_INTESTINE

Explore this box plot interactively →