PRKDC

Across TCGA patient cohorts, PRKDC mutation is significantly associated with the RNA expression of many other genes, with 8,525 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKDC-associated genes across cancer lineages are UBE2T, ZWINT, and ZNF232. Each is linked with PRKDC in more than 6 cancer types. Because this analysis shows association rather than direction, both PRKDC-to-partner and partner-to-PRKDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2T grouped by PRKDC-low versus PRKDC-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKDC→partner) and Y-score (partner→PRKDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	UBE2T →	+0.554	+2.177	.006	.001	3	7
UCEC	ZWINT →	+0.554	+1.710	<.001	<.001	3	6
COAD	ZNF232 →	+0.521	+2.247	<.001	.001	3	6
SKCM	PPP2R2D →	+0.310	+1.616	<.001	<.001	3	6
SKCM	PRANCR →	+0.464	+1.700	<.001	.002	3	6
STAD	UCHL5 →	+0.303	+3.492	.007	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,525 associations by consensus.

UBE2T by PRKDC expression — BLCA

Explore this box plot interactively →