PRKDC

Across TCGA patient cohorts, PRKDC mutation is significantly associated with the total protein of many other genes, with 87 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKDC-associated genes across cancer lineages are Caspase-7-cleavedD198, c-Kit, and 4E-BP1. Each is linked with PRKDC in more than 4 cancer types. Because this analysis shows association rather than direction, both PRKDC-to-partner and partner-to-PRKDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PRKDC-low versus PRKDC-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKDC→partner) and Y-score (partner→PRKDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.960	+2.717	<.001	.002	3	5
STAD	c-Kit →	-0.291	-2.321	.013	.005	3	5
STAD	4E-BP1 →	+0.294	+3.459	.008	.004	3	5
HNSC	Cyclin-E1 →	+0.267	+3.000	.037	.035	3	4
BLCA	ER-alpha →	-0.180	-2.982	.023	<.001	3	4
COAD	PCNA →	+0.249	+1.934	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

Caspase-7-cleavedD198 by PRKDC expression — COAD

Explore this box plot interactively →