PRKDC

Across TCGA cell cohorts, PRKDC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,287 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRKDC-associated GO terms across cancer lineages are Double-strand break repair via break-induced replication, DNA replication, and DNA-templated DNA replication. Each is linked with PRKDC in more than 18 cancer types. Because this analysis shows association rather than direction, both PRKDC-to-partner and partner-to-PRKDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via break-induced replication grouped by PRKDC-low versus PRKDC-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKDC→partner) and Y-score (partner→PRKDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Double-strand break repair via break-induced replication →	+0.202	+0.772	<.001	<.001	3	19
BONE	DNA replication →	+0.110	+0.864	.002	.005	3	19
BONE	DNA-templated DNA replication →	+0.135	+1.004	.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.169	+1.318	<.001	<.001	3	19
OESOPHAGUS	Chromosome segregation →	+0.140	+1.065	.003	.002	3	19
SOFT_TISSUE	Positive regulation of cell cycle process →	+0.094	+0.940	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,287 associations by consensus.

Double-strand break repair via break-induced replication by PRKDC expression — PANCREAS

Explore this box plot interactively →