PRKDC

Across TCGA cell cohorts, PRKDC mutation is significantly associated with the RNA expression of many other genes, with 2,804 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKDC-associated genes across cancer lineages are CENPM, TTC26, and MTPAP. Each is linked with PRKDC in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKDC-to-partner and partner-to-PRKDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPM grouped by PRKDC-low versus PRKDC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKDC→partner) and Y-score (partner→PRKDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CENPM →	+0.715	+3.321	<.001	.002	3	3
LARGE_INTESTINE	TTC26 →	+0.432	+2.649	.002	.001	3	3
LARGE_INTESTINE	MTPAP →	+0.583	+2.628	<.001	<.001	3	3
LARGE_INTESTINE	YWHAE →	+0.543	+2.130	<.001	<.001	3	3
LARGE_INTESTINE	LANCL1 →	+0.846	+2.130	<.001	<.001	3	3
LARGE_INTESTINE	TAS2R4 →	+0.331	+2.115	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,804 associations by consensus.

CENPM by PRKDC expression — LARGE_INTESTINE

Explore this box plot interactively →