PRKD3

Across TCGA pan-cancer cohorts, PRKD3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PRKD3 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PRKD3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRKD3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where PRKD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.246	1.000	.008	24	view →
HNSC	DFS	Median	II,III,IV	0.911	1.000	.005	9	view →
LSCC	DFS	Tertile	II,III,IV	0.561	0.888	.027	4	view →
LUAD	DFS	Quartile	II,III,IV	0.761	0.253	.017	3	view →
CCRCC	OS	Tertile	III,IV	1.000	0.310	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PRKD3–UCEC (DFS)

Open the UCEC breakdown →