PRKD3

Across TCGA patient cohorts, PRKD3 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKD3-associated genes across cancer lineages are ATM, p21, and STAT3_pY705. Each is linked with PRKD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKD3-to-partner and partner-to-PRKD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PRKD3-low versus PRKD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKD3→partner) and Y-score (partner→PRKD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.569	-1.836	<.001	.001	3	3
UCEC	p21 →	+0.119	+2.222	.049	.010	3	2
UCEC	STAT3_pY705 →	-0.392	-2.662	<.001	<.001	3	2
UCEC	ASNS →	+0.405	+1.662	<.001	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.470	+1.522	.011	.017	3	2
UCEC	CD20 →	+0.083	+1.300	.045	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ATM by PRKD3 expression — UCEC

Explore this box plot interactively →