PRKD3

Across TCGA cell cohorts, PRKD3 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRKD3-associated genes across cancer lineages are GYS2, MUC7, and DMRTC2. Each is linked with PRKD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKD3-to-partner and partner-to-PRKD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GYS2 grouped by PRKD3-low versus PRKD3-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKD3→partner) and Y-score (partner→PRKD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GYS2 →	+0.066	+3.906	<.001	.009	3	1
BLOOD_Myeloma	MUC7 →	+0.023	+3.906	<.001	.009	3	1
CNS	DMRTC2 →	+0.119	+5.321	<.001	.005	3	1
CNS	OR4X2 →	+0.044	+4.981	<.001	.008	3	1
CNS	ACSM2B →	+0.013	+5.321	<.001	.005	3	1
BLOOD_Leukemia	ASB10 →	+0.058	+3.551	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GYS2 by PRKD3 expression — BLOOD_Myeloma

Explore this box plot interactively →