PRKD3

Across TCGA cell cohorts, PRKD3 mutation is significantly associated with the mutation status of many other genes, with 2,442 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKD3-associated genes across cancer lineages are TRPM3, USP19, and CBLB. Each is linked with PRKD3 in more than 4 cancer types. Because this analysis shows association rather than direction, both PRKD3-to-partner and partner-to-PRKD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRPM3 grouped by PRKD3-low versus PRKD3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKD3→partner) and Y-score (partner→PRKD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TRPM3 →	+2.465	+3.156	.005	.005	1	5
LUNG_NSCLC_LUAD	USP19 →	+4.187	+5.000	.008	.008	1	4
BLOOD_Lymphoma	CBLB →	+6.169	+6.169	<.001	<.001	1	4
BLOOD_Leukemia	RBM26 →	+4.050	+4.260	<.001	<.001	1	4
LARGE_INTESTINE	NTRK2 →	+3.799	+3.329	.005	.005	1	4
LARGE_INTESTINE	ZBTB10 →	+2.630	+3.047	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,442 associations by consensus.

TRPM3 by PRKD3 expression — BLOOD_Leukemia

Explore this box plot interactively →