PRKD2

Across TCGA patient cohorts, PRKD2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKD2-associated genes across cancer lineages are PDCD4, PCNA, and NF-kB-p65_pS536. Each is linked with PRKD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKD2-to-partner and partner-to-PRKD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by PRKD2-low versus PRKD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKD2→partner) and Y-score (partner→PRKD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.587	-2.201	<.001	<.001	3	3
COAD	PCNA →	+0.368	+3.012	.004	.018	3	3
UCEC	NF-kB-p65_pS536 →	-0.321	-1.668	.035	.021	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.634	-2.188	<.001	<.001	3	3
UCEC	ATM →	-0.481	-1.807	.001	.025	3	3
COAD	ASNS →	+0.703	+3.008	<.001	.019	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

PDCD4 by PRKD2 expression — UCEC

Explore this box plot interactively →