PRKD2

Across TCGA cell cohorts, PRKD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,788 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKD2-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Morphogenesis of an endothelium, and Endothelial tube morphogenesis. Each is linked with PRKD2 in more than 12 cancer types. Because this analysis shows association rather than direction, both PRKD2-to-partner and partner-to-PRKD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by PRKD2-low versus PRKD2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKD2→partner) and Y-score (partner→PRKD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of calcium ion export across plasma membrane →	+0.097	+0.931	<.001	<.001	3	12
URINARY_TRACT	Morphogenesis of an endothelium →	+0.177	+0.607	<.001	.007	2	13
URINARY_TRACT	Endothelial tube morphogenesis →	+0.177	+0.607	<.001	.007	2	13
UPPER_AERODIGESTIVE_TRACT	Regulation of pattern recognition receptor signaling pathway →	+0.075	+0.591	<.001	<.001	3	11
BLOOD_Myeloma	Regulation of calcium ion export across plasma membrane →	+0.132	+1.496	.002	.003	3	11
BREAST	Regulation of protein localization to nucleus →	+0.076	+0.774	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,788 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by PRKD2 expression — BONE

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